Registered Nurse Salary Guide: San Luis Obispo, CA
Average Registered Nurse Salary
$49.31/hour
The average salary for a Registered Nurse in San Luis Obispo, CA is $49.31 per hour. This is 47% lower than the California average of $72.66.
Estimate based on Bureau of Labor Statistics data.
Registered Nurse salaries in San Luis Obispo, CA compared to State and National Averages
$49.31/hour
San Luis Obispo, CA
19% higher than the US average.
$72.66/hour
California
45% higher than the US average.
$40.02/hour
United States
How Registered Nurse Salaries in San Luis Obispo Compare to Other Cities
How Registered Nurse Salaries in San Luis Obispo Compare to Other Cities
Fresno, California
$65/hour
This is 24% higher than the San Luis Obispo average of $49.31.
Thousand Oaks, California
$46/hour
This is 7% lower than the San Luis Obispo average of $49.31.
San Francisco, California
$66/hour
This is 26% higher than the San Luis Obispo average of $49.31.
What are the highest paying Agencies for Registered Nurse jobs in San Luis Obispo?
| Average Hourly Salary | Max Hourly Salary | |
|---|---|---|
| Adventist Health | $65 | $75 |
Last updated on January 4, 2026. Information based on active jobs on Vivian.com and pay data from BLS and around the web.
Top Registered Nurse Jobs
Registered Nurse (RN) - Manager, Labor and Delivery
- Adventist Health
- San Luis Obispo, CA
$146K-219K/year
Lead Registered Nurse (RN) - ICU - Intensive Care Unit
- Adventist Health
- San Luis Obispo, CA
$60-90/hour
Lead Registered Nurse (RN) - Labor and Delivery
- Adventist Health
- San Luis Obispo, CA
$60-90/hour
Lead Registered Nurse (RN) - NICU - Neonatal Intensive Care
- Adventist Health
- San Luis Obispo, CA
$60-90/hour
Registered Nurse (RN) - OR - Operating Room
- Adventist Health
- San Luis Obispo, CA
$24-28/hour
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